Footnotes

• Competing interests

  The authors declare no competing or financial interests.

• Author contributions

  Conceptualization: I.J.B., K.S., F.J.P., J.K.; Methodology: I.J.B., K.S., D.O.-M., A.K., J.K.; Validation: I.J.B., K.S., D.O.-M.; Formal analysis: I.J.B., K.S.; Ivestigation: I.J.B., K.S., D.O.-M., A.K.,J.K.; Resources: I.J.B., K.S., N.L., T.J.C., F.J.P., J.K.; Writing - original draft: I.J.B., J.K.; Writing - review & editing: I.J.B., K.S., D.O.-M., J.K.; Visualization: I.J.B., K.S., D.O.-M., J.K.; Supervision: J.K.; Project administration: I.J.B., K.S., J.K.; Funding acquisition: F.J.P., J.K.

• Funding

  This work was supported by the National Institutes of Health, under a Ruth L. Kirschstein National Research Service Award from the National Heart, Lung and Blood Institute to the University of Wisconsin-Madison Cardiovascular Research Center (T32 HL 007936 to I.J.B.) and from the National Institute Of General Medical Sciences to the University of Wisconsin-Madison Genetics Graduate Training Program (T32 GM 007133 to T.J.C. and D.O.-M.), by a U.S. Department of Agriculture Hatch grant and the University of Wisconsin-Madison UW2020 Round 6 award to F.J.P., by the National Institutes of Health (R35 GM 137878), by University of Wisconsin-Madison start-up funds (AAC8355, AAC8979, AAC6429 and AAG9756), by an American Heart Association grant (AHA16SDG30020001 to J.K.), and by a University of Wisconsin Carbone Cancer Center Support Grant (P30 CA014520 to J.K.). Deposited in PMC for release after 12 months.

• Supplementary information

  Supplementary information available online at https://dev.biologists.org/lookup/doi/10.1242/dev.194019.supplemental