This issue is currently being compiled. Articles in their final version of record are published here as soon as they are ready. The most recent articles appear at the top of the relevant section. More information on our new continuous publication model can be found here.
RESEARCH HIGHLIGHTS
OBITUARY
- Obituary: Friedrich Bonhoeffer (1932-2021)
Summary: Uwe Drescher commemorates the life and work of Friedrich Bonhoeffer, whose pioneering work – including the development of innovative in vitro assays – led to important discoveries in the field of axon guidance and neural development.
INTERVIEW
REVIEWS
- Dynamic properties of mitochondria during human corticogenesis
Summary: This Review highlights the mechanisms by which the dynamic properties of the mitochondria impact human cortical development.
- Understanding axial progenitor biology in vivo and in vitro
Summary: This Review looks at the biology of the progenitors that generate the components that make up the embryonic body axis, such as the spinal cord and vertebral column, as well as their in vitro production and potential applications in disease modelling and regenerative medicine.
- Craniofacial transitions: the role of EMT and MET during head development
Summary: Within the developing head, tissues undergo cell-fate transitions to shape the forming structures. This Review focuses on the processes of EMT and MET.
HUMAN DEVELOPMENT
- 4D formation of human embryonic forelimb musculature
Summary: A detailed 4D anatomical description of the human upper limb musculature through embryonic development reveals important events that enable nascent muscle bundles to form correctly.
STEM CELLS AND REGENERATION
- Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain
Summary: Hes1 overexpression leads to expansion of the embryonic neural stem cell pool, including basal radial glia-like cells, and enhanced neurogenesis in the postnatal brain by expanding the neural stem cell reservoir.
- Oxygen regulates epithelial stem cell proliferation via RhoA-actomyosin-YAP/TAZ signal in mouse incisor
Highlighted Article: The crucial role of microenvironmental oxygen in epithelial stem cell compartments is shown using a mouse incisor model, also providing insights into the associated signaling pathway regulation.
RESEARCH ARTICLES
- Precision of tissue patterning is controlled by dynamical properties of gene regulatory networks
Summary: Experiments and modeling reveal sharp boundaries of gene expression in the vertebrate neural tube depend on the dynamics of the gene regulatory network that patterns the tissue.
- Stem integrity in Arabidopsis thaliana requires a load-bearing epidermis
Summary: This study tests the epidermal growth theory by investigating the roles of CLV3 and DET3 in sustaining flowering stem structural integrity.
- Tissue growth constrains root organ outlines into an isometrically scalable shape
Highlighted Article: The dome-shaped outlines of plant root tips converge to a parameter-free catenary curve seen in arch bridges, owing to a constraint from anisotropic and localized tissue growth.
- A dynamic and mosaic basement membrane controls cell intercalation in Drosophila ovaries
Highlighted Article: Dynamic assembly of Collagen IV from multiple tissues is essential for cell intercalation, the production of functional, mechanically resistant ovarioles and, hence, fertility.
- Roles of developmentally regulated KIF2A alternative isoforms in cortical neuron migration and differentiation
Summary: The three different isoforms of KIF2A expressed during embryonic corticogenesis have different roles, and proximity ligation proteomics shows the presence of isoform-specific protein interactomes.
- Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk
Summary: Vasohibin 1-mediated detyrosination of endothelial microtubules is selectively required for the control of venous secondary sprouting and subsequent formation of functional lymphatics in the zebrafish trunk.
- HoxB genes regulate neuronal delamination in the trunk neural tube by controlling the expression of Lzts1
Summary: Instead of providing positional information, HoxB genes regulate the delamination of neuronally differentiating cells by controlling the expression of leucine zipper tumor suppressor 1.
- Feedback control of the Gpr161-Gαs-PKA axis contributes to basal Hedgehog repression in zebrafish
Summary: Loss of Gpr161 leads to reduced PKA activity and derepression of Hedgehog signalling in zebrafish. Additionally, PKA-mediated phosphorylation of Gpr161 controls its ciliary localisation to fine-tune Hedgehog signalling activity.
- Retinoic acid production, regulation and containment through Zic1, Pitx2c and Cyp26c1 control cranial placode specification
Summary: A spatially restricted program of retinoic acid production and degradation is established by Zic1 and its targets Cyp26c1 and Pitx2c to pattern the precursor region for all paired sensory organs.
- Ciliopathic micrognathia is caused by aberrant skeletal differentiation and remodeling
Summary: Ciliopathic micrognathia is caused by aberrant Gli-mediated signaling, which results in impaired differentiation of neural crest cells, failed osteoblast maturation and excessive bone resorption.
This issue
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Other journals from The Company of Biologists
An interview with Swathi Arur
Swathi Arur joined the team at Development as an Academic Editor in 2020. Her lab uses multidisciplinary approaches to understand female germline development and fertility. We met with her over Zoom to hear more about her life, her career and her love for C. elegans.
Jim Wells and Hanna Mikkola join our team of Editors
We are pleased to welcome James (Jim) Wells and Hanna Mikkola to our team of Editors. Jim joins us a new Academic Editor, taking over from Gordan Keller, and Hanna joins our team of Associate Editors. Find out more about their research interests and areas of expertise.
New funding scheme supports sustainable events
As part of our Sustainable Conferencing Initiative, we are pleased to announce funding for organisers that seek to reduce the environmental footprint of their event. The next deadline to apply for a Scientific Meeting grant is 26 March 2021.
Read & Publish participation continues to grow
“I’d heard of Read & Publish deals and knew that many universities, including mine, had signed up to them but I had not previously understood the benefits that these deals bring to authors who work at those universities.”
Professor Sally Lowell (University of Edinburgh) shares her experience of publishing Open Access as part of our growing Read & Publish initiative. We now have over 150 institutions in 15 countries and four library consortia taking part – find out more and view our full list of participating institutions.
Upcoming special issues
Imaging Development, Stem Cells and Regeneration
Submission deadline: 30 March 2021
Publication: mid-2021
The Immune System in Development and Regeneration
Guest editors: Florent Ginhoux and Paul Martin
Submission deadline: 1 September 2021
Publication: Spring 2022
Both special issues welcome Review articles as well as Research articles, and will be widely promoted online and at key global conferences.
Development presents...
Our successful webinar series continues into 2021, with early-career researchers presenting their papers and a chance to virtually network with the developmental biology community afterwards. Here, Michèle Romanos talks about her new preprint, which mixes experimentation in quail embryos and computational modelling to understand how heterogeneity in a tissue influences cell rate.
Save your spot at our next session:
10 March
Time: 9:00 (GMT)
Chaired by: Thomas Lecuit
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