PT  - JOURNAL ARTICLE
AU  - Sawada, Atsushi
AU  - Shinya, Minori
AU  - Jiang, Yun-Jin
AU  - Kawakami, Atsushi
AU  - Kuroiwa, Atsushi
AU  - Takeda, Hiroyuki
TI  - Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
DP  - 2001 Dec 01
TA  - Development
PG  - 4873--4880
VI  - 128
IP  - 23
4099  - http://dev.biologists.org/content/128/23/4873.short
4100  - http://dev.biologists.org/content/128/23/4873.full
SO  - Development2001 Dec 01; 128
AB  - The temporal and spatial regulation of somitogenesis requires a molecular oscillator, the segmentation clock. Through Notch signalling, the oscillation in cells is coordinated and translated into a cyclic wave of expression of hairy-related and other genes. The wave sweeps caudorostrally through the presomitic mesoderm (PSM) and finally arrests at the future segmentation point in the anterior PSM. By experimental manipulation and analyses in zebrafish somitogenesis mutants, we have found a novel component involved in this process. We report that the level of Fgf/MAPK activation (highest in the posterior PSM) serves as a positional cue within the PSM that regulates progression of the cyclic wave and thereby governs the positions of somite boundary formation.