PT  - JOURNAL ARTICLE
AU  - Williams, Darren W.
AU  - Shepherd, David
TI  - Persistent larval sensory neurones are required for the normal development of the adult sensory afferent projections in <em>Drosophila</em>
DP  - 2002 Feb 01
TA  - Development
PG  - 617--624
VI  - 129
IP  - 3
4099  - http://dev.biologists.org/content/129/3/617.short
4100  - http://dev.biologists.org/content/129/3/617.full
SO  - Development2002 Feb 01; 129
AB  - We have tested the hypothesis that larval neurones guide growth of adult sensory axons in Drosophila. We show that ablation of larval sensory neurones causes defects in the central projections of adult sensory neurones. Spiralling axons and ectopic projections indicate failure in axon growth guidance. We show that larval sensory neurones are required for peripheral pathfinding, entry into the CNS and growth guidance within the CNS. Ablation of subsets of neurones shows that larval sensory neurones serve specific guidance roles. Dorsal neurones are required for axon guidance across the midline, whereas lateral neurones are required for posterior growth. We conclude that larval sensory neurones pioneer the assembly of sensory arrays in adults.