PT  - JOURNAL ARTICLE
AU  - Jhaveri, Dhanisha
AU  - Rodrigues, Veronica
TI  - Sensory neurons of the Atonal lineage pioneer the formation of glomeruli within the adult <em>Drosophila</em> olfactory lobe
DP  - 2002 Mar 01
TA  - Development
PG  - 1251--1260
VI  - 129
IP  - 5
4099  - http://dev.biologists.org/content/129/5/1251.short
4100  - http://dev.biologists.org/content/129/5/1251.full
SO  - Development2002 Mar 01; 129
AB  - The first centers for processing of odor information by animals lie in the olfactory lobe. Sensory neurons from the periphery synapse with interneurons in anatomically recognizable units, termed glomeruli, seen in both insects and vertebrates. The mechanisms that underlie the formation of functional maps of the odor-world in the glomeruli within the olfactory lobe remains unclear. We address the basis of sensory targeting in the fruitfly Drosophila and show that one class of sensory neurons, those of the Atonal lineage, plays a crucial role in glomerular patterning. Atonal-dependent neurons pioneer the segregation of other classes of sensory neurons into distinct glomeruli. Furthermore, correct sensory innervation is necessary for the arborization of projection neurons into glomeruli and for the elaboration of processes of central glial cells into the lobe.