RT Journal Article
SR Electronic
T1 Hypogonadotropic hypogonadism and peripheral neuropathy in

<em>Ebf2</em>-null mice
JF Development
JO Development
FD The Company of Biologists Limited
SP 401
OP 410
DO 10.1242/dev.00215
VO 130
IS 2
A1 Corradi, Anna
A1 Croci, Laura
A1 Broccoli, Vania
A1 Zecchini, Silvia
A1 Previtali, Stefano
A1 Wurst, Wolfgang
A1 Amadio, Stefano
A1 Maggi, Roberto
A1 Quattrini, Angelo
A1 Consalez, G. Giacomo
YR 2003
UL http://dev.biologists.org/content/130/2/401.abstract
AB Olf/Ebf transcription factors have been implicated in numerous developmental processes, ranging from B-cell development to neuronal differentiation. We describe mice that carry a targeted deletion within the Ebf2 (O/E3) gene. In Ebf2-null mutants, because of defective migration of gonadotropin releasing hormone-synthesizing neurons, formation of the neuroendocrine axis (which is essential for pubertal development) is impaired, leading to secondary hypogonadism. In addition, Ebf2-/- peripheral nerves feature defective axon sorting, hypomyelination, segmental dysmyelination and axonal damage, accompanied by a sharp decrease in motor nerve conduction velocity. Ebf2-null mice reveal a novel genetic cause of hypogonadotropic hypogonadism and peripheral neuropathy in the mouse, disclosing an important role for Ebf2 in neuronal migration and nerve development.