RT Journal Article
SR Electronic
T1 Efficient regeneration by activation of neurogenesis in homeostatically quiescent regions of the adult vertebrate brain
JF Development
JO Development
FD The Company of Biologists Limited
SP 4127
OP 4134
DO 10.1242/dev.055541
VO 137
IS 24
A1 Berg, Daniel A.
A1 Kirkham, Matthew
A1 Beljajeva, Anna
A1 Knapp, Dunja
A1 Habermann, Bianca
A1 Ryge, Jesper
A1 Tanaka, Elly M.
A1 Simon, András
YR 2010
UL http://dev.biologists.org/content/137/24/4127.abstract
AB In contrast to mammals, salamanders and teleost fishes can efficiently repair the adult brain. It has been hypothesised that constitutively active neurogenic niches are a prerequisite for extensive neuronal regeneration capacity. Here, we show that the highly regenerative salamander, the red spotted newt, displays an unexpectedly similar distribution of active germinal niches with mammals under normal physiological conditions. Proliferation zones in the adult newt brain are restricted to the forebrain, whereas all other regions are essentially quiescent. However, ablation of midbrain dopamine neurons in newts induced ependymoglia cells in the normally quiescent midbrain to proliferate and to undertake full dopamine neuron regeneration. Using oligonucleotide microarrays, we have catalogued a set of differentially expressed genes in these activated ependymoglia cells. This strategy identified hedgehog signalling as a key component of adult dopamine neuron regeneration. These data show that brain regeneration can occur by activation of neurogenesis in quiescent brain regions.