PT  - JOURNAL ARTICLE
AU  - Campbell, Kyra
AU  - Casanova, Jordi
TI  - A common framework for EMT and collective cell migration
AID  - 10.1242/dev.139071
DP  - 2016 Dec 01
TA  - Development
PG  - 4291--4300
VI  - 143
IP  - 23
4099  - http://dev.biologists.org/content/143/23/4291.short
4100  - http://dev.biologists.org/content/143/23/4291.full
SO  - Development2016 Dec 01; 143
AB  - During development, cells often switch between static and migratory behaviours. Such transitions are fundamental events in development and are linked to harmful consequences in pathology. It has long been considered that epithelial cells either migrate collectively as epithelial cells, or undergo an epithelial-to-mesenchymal transition and migrate as individual mesenchymal cells. Here, we assess what is currently known about in vivo cell migratory phenomena and hypothesise that such migratory behaviours do not fit into alternative and mutually exclusive categories. Rather, we propose that these categories can be viewed as the most extreme cases of a general continuum of morphological variety, with cells harbouring different degrees or combinations of epithelial and mesenchymal features and displaying an array of migratory behaviours.