RT Journal Article
SR Electronic
T1 A common framework for EMT and collective cell migration
JF Development
JO Development
FD The Company of Biologists Limited
SP 4291
OP 4300
DO 10.1242/dev.139071
VO 143
IS 23
A1 Campbell, Kyra
A1 Casanova, Jordi
YR 2016
UL http://dev.biologists.org/content/143/23/4291.abstract
AB During development, cells often switch between static and migratory behaviours. Such transitions are fundamental events in development and are linked to harmful consequences in pathology. It has long been considered that epithelial cells either migrate collectively as epithelial cells, or undergo an epithelial-to-mesenchymal transition and migrate as individual mesenchymal cells. Here, we assess what is currently known about in vivo cell migratory phenomena and hypothesise that such migratory behaviours do not fit into alternative and mutually exclusive categories. Rather, we propose that these categories can be viewed as the most extreme cases of a general continuum of morphological variety, with cells harbouring different degrees or combinations of epithelial and mesenchymal features and displaying an array of migratory behaviours.