RT Journal Article
SR Electronic
T1 Toll and Toll-like receptor signalling in development
JF Development
JO Development
FD The Company of Biologists Limited
SP dev156018
DO 10.1242/dev.156018
VO 145
IS 9
A1 Anthoney, Niki
A1 Foldi, Istvan
A1 Hidalgo, Alicia
YR 2018
UL http://dev.biologists.org/content/145/9/dev156018.abstract
AB The membrane receptor Toll and the related Toll-like receptors (TLRs) are best known for their universal function in innate immunity. However, Toll/TLRs were initially discovered in a developmental context, and recent studies have revealed that Toll/TLRs carry out previously unanticipated functions in development, regulating cell fate, cell number, neural circuit connectivity and synaptogenesis. Furthermore, knowledge of their molecular mechanisms of action is expanding and has highlighted that Toll/TLRs function beyond the canonical NF-κB pathway to regulate cell-to-cell communication and signalling at the synapse. Here, we provide an overview of Toll/TLR signalling and discuss how this signalling pathway regulates various aspects of development across species.