Table 2.

Frequency of genotypic and phenotypic classes

AgeChrd-/-;Nog+/+Chrd-/-;Nog+/-Chrd-/-;Nog-/-Number of rostral phenotypes in Chrd-/-;Nog+/-
E7.530 (29.4%)50 (49%)22 (21.6%)0
E8.566 (29%)116 (51%)46 (20%)9 (8%)
E9.540 (27%)80 (55%)26 (18%)8 (10%)
E17.524 (38%)38 (60%)1 (1.6%)4 (11%)
P2867 (40%)96 (60%)00
  • These data represent only a subset of total embryos examined. Double null phenotypes were essentially as described (Bachiller et al., 2000). All rostralrestricted phenotypes genotyped as Chrd-/-;Nog+/-. Penetrance was calculated as the percentage of Chrd-/-;Nog+/- animals with phenotypes. At weaning, Chrd-/-;Nog+/- mice were under-represented by 11.7% (P=0.035).