Table 3.

Frequency of rostral deletion phenotypes in different genetic backgrounds

StrainChrd-/-;Nog+/+Chrd+/+;Nog+/-Chrd-/-;Nog+/-Chrd-/-;Nog-/-
129SVJ (inbred)1.8%; n=570%; n=1270%; n=5*n/a*
B6SJLF1 (hybrid)0%; n>1000%; n>1004.5%; n=22100%
ICR (outbred)0%; n>4030%; n>1749.0%; n=234100%; n>73
  • Embryos of each genotype were examined for rostral midline or truncation phenotypes between the ages of E9.5 and P28.

    n/a, not applicable.

  • * Low fecundity in 129 background prevented detailed study of double mutants.

  • Bachiller et al., 2000.