Table 1.

Kidney abnormalities in newborn compound heterozygotes of Eya1 and Six1

GenotypenSmall kidneyNo kidney
Wild type 1291300
Eya1+/- 129173*0
Six1+/- 129192One bilateral
Eya1+/-/Six1+/- 1292115Five bilateral, one unilateral
Wild type C57BL6160One unilateral
Eya1+/- C57BL6131§0
Six1+/- C57BL61200
Eya1+/-/Six1+/- C57BL61410Four unilateral
  • n, number of animals

  • * Three Eya1+/- 129 animals showed unilaterally smaller kidney with reduction of ∼10% in weight

  • Two Six1+/- 129 animals showed smaller kidneys on one side, with reduction of ∼10-15% in weight

  • Fifteen Eya1/Six1 129 compound heterozygotes showed small kidneys either bilaterally (n=9) or unilaterally (n=6), with reduction of ∼75-22% in weight

  • § One Eya1+/- C57BL6 animal showed smaller kidney on one side, with reduction of ∼15% in weight

  • Ten Eya1/Six1 C57BL6 compound heterozygotes showed small kidneys either unilaterally (n=6) or bilaterally (n=4). Weight reduction was from 20 to 30%, less severe than that observed in 129 background