Table 1.

Developmental status and function of kidneys in newborn Brn1 mutant mice

Genotype
+/++/−−/−
Body weight (g)1.54±0.071.56±0.031.40±0.03
Kidney weight (g)0.015±0.0010.015±0.0010.012±0.001
BUN (serum) (mg/dl)26.7±1.726.9±1.144.2±4.2
K (serum) (mEq/l)4.8±0.15.2±0.17.2±0.8
Numbers of glomeruli*44.2±6.847.7±1.642.3±4.7
Glomerular maturity index2.03±0.052.02±0.031.96±0.03
  • Mean±s.e.m. (n≥6).

  • * Numbers of glomeruli were counted in the median longitudinal section.

  • P<0.05 versus +/+ by t-test, following ANOVA.