Table 1.

Summary of phenotypes in pitx2 mutant allelic combinations

GenotypeMolar phenotypeFgf8 signalingBmp signaling
δabcnull;+/-NormalNormalNormal
δabcnull;-/-Arrested bud stageMaintenance defectStrongly expanded
δabcnull; δabhypocDefect prior to cap formationNormalWeakly expanded
δabcnull; δabMolar orientation defectNormalWeakly expanded
δab; δcNormaln.d.n.d.
δab; δabNormalNormalNormal
δc; δcNormalNormalNormal