Table 4.

Enhancement of mfn/mfn dorsalization by sub-dorsalizing tsg1 knockdown

C3C1Wild type
Uninjected (n=131)*0%21%79%
Injected mfn/mfn (n=113)76%24%0%
Injected mfn/+ or +/+ (n=239)5%1%94%
  • * Uninjected embryos from intercrosses of mfn heterozygotes. Only the mfn homozygotes displayed a C1 phenotype, as confirmed by genotypic analysis

  • 12.5 ng MO5 injected per embryo from crosses of two mfn heterozygotes. Following morphological classification, all embryos were genotyped