Table 1.

Quantitative analysis of the phenotypes in neurogenesis and proliferation of mouse mutants with specific defects in Pax6 DNA-binding domains

Thickness of cortical plate (neurons)/thickness of entire cortexProliferation/area (number of PH3+ cells per radial stripe of 150 μm) at ventricular surfaceProliferation/area (number of PH3+ cells per radial stripe of 150 μm) at subventricular zoneProliferation/area (total number of PH3+ cells per radial stripe of 150 μm)Percent abventricular mitosis per hemisphere
Wild type0.25±0.03913.9±4.24.9±2.618.824.2±5.2
Pax6Aey18–/–0.21±0.0311 P<0.00912.8±2.5 P<0.45313.3±2.9 P<1.8×10-726.142.0±8.7
Wild type0.25±0.07011.8±2.05.9±3.117.726.1±6.0
Pax6(5a)–/–0.22±0.064 P<0.112.3±3.4 P<0.6614.3±2.1 P<0.14316.625.4±4.2
Wild type0.23±0.05515.1±5.36.3±4.521.429.7±7.4
Pax64Neu–/–0.23±0.029 P<0.813.1±3.8 P<0.3115.9±3.8 P<0.8471927.2±5.5
Wild type0.23±0.03516.3±6.37.8±6.724.116.0±6.9
Pax6Sey–/–0.17±0.041 P<0.000717.1±5.6 P<0.83119.1±5.6 P<9.8×10-536.235.8±5.2
  • All values are given as mean±s.d., n=12.