Table 1.

Known genes whose expression changes in the absence of Brn3b

Accession Number*Gene nameFCFC (PCR)p-value§SE
Transcription factors
S69351Brn3b/Brn-3.2/Pou4f2−5.06-0.000RGC
L12147Olf-1/EBF1−4.27−8.00.000RGC
S69350Brn3a/Brn-3.0/Pou4f1−3.82−4.60.000RGC
AF295369Irx2−3.81−5.70.000RGC
AB025922Gli 1−2.99−6.10.000Progenitor
AB015132Ubiquitous Kruppel like factor−1.87ND0.000Unknown
U51000Dlx-12.184.00.002Progenitor
NM_009380Thyroid T3 hormone receptor beta2.91ND0.001Non-RGC
NM_010054Dlx-2NA2.8Progenitor
Neuron integrity and function
AF099986Persyn/synuclein-γ−13.60−42.20.000RGC
S59158EAAT-2/GluT1−3.83−6.90.000Non-RGC
NM_013031**VMAT-2−3.00−16.00.000RGC
J02809GAP-43−2.99−2.10.000RGC
U10355Synaptotagmin 4−2.73−6.90.000RGC
AF148511Hermes−2.53−4.90.000RGC
M20480Neurofilament light chain−2.48−3.70.000RGC
AF091342Nerurofilament medium chain−2.41−2.60.000RGC
U62325FE65-like protein−2.35ND0.000Unknown
M16465Calpactin I light chain−2.30−5.30.000Unknown
AB048947Synaptotagmin 13−2.30ND0.000RGC
U59230Nel-like 2 (nell2)−2.19−16.00.000Unknown
D50086Neuropilin 1−1.96−2.60.000Unknown
M18776Tau microtubule binding protein−1.83−2.40.000RGC
AY043013††Neuron navigator 1 (NAV1)1.95ND0.002Unknown
Signaling and cell cycle
X76290Sonic hedgehogNA−78.8RGC
AF033855Myostatin/GDF8−2.05−12.10.000RGC
AB010833Ptc2NA−4.9Progenitor
S78355Cyclin D1−2.50−2.40.000Progenitor
Others
D45913Leucine-rich-repeat protein−2.46ND0.000Unknown
AF292939Glucocorticoid induced gene 1, Gig1−2.33−2.00.000Unknown
AP001748U2 snRNP auxiliary factor−2.25ND0.000Unknown
BC001993Protein phosphatase 4−2.18ND0.000Unknown
BC017139RIKEN 2310067G05 gene−2.15ND0.000Unknown
NM_145377Tripartite motif-containing 41−2.12ND0.000Unknown
XM_196206RIKEN 2610209L21 gene−2.11ND0.000Unknown
AF012271Visual pigment-like receptor−2.10ND0.000Unknown
AJ414378Putative methionyl aminopeptidase−2.00ND0.000Unknown
D13635††Ubiquitin-protein isopeptide ligase E3−1.98ND0.000Unknown
XM_128169RIKEN 1810041L15 gene (RGCG1)−1.91−2.60.000RGC
AB051466KIAA1679 protein−1.87ND0.000Unknown
U17259p19−1.86ND0.001Unknown
U17599Ribonucleoprotein−1.80−2.60.000Unknown
Y15924Cystinosin−1.76ND0.000Unknown
AH009472Phosphofructokinase 1 C isozyme−1.71ND0.001Unknown
M17300Cholesterol-regulated protein C−1.70ND0.000Unknown
AE003460MTMR61.63ND0.002Unknown
Z49204NADP transhydrogenase1.851.90.001Unknown
BC006058RIKEN 2510049I19 gene1.92ND0.001Unknown
NM_025940RIKEN 2610042L04 gene2.522.30.001Unknown
  • * GenBank Accession Number. Rat (**) or human (††) Accession Numbers are shown for genes without a mouse entry in GenBank.

  • Average fold change from microarray experiments. Negative numbers mean reduction in expression in the absence of Brn3b and positive numbers mean increase in expression.

  • Fold change determined by real-time PCR. ND, not determined.

  • § P value (Student's t-test) based on the microarray data. The value is presented as 0.000 when it is less than 0.0005.

  • Spatial expression pattern.