Table 2.

Microarray analysis of Pkbγ mutant brain

Fold change in expression
Gene nameGenBank Accession NumberDay 1Day 7Day 30Function
RIO kinase 3 (yeast)AK0047485.47*0.591.52*Chromatin condensation
Kinesin family member 5BBF0996322.24*0.721.03Microtubule based transport
Small EDRK-rich factor 1AA7099931.69*1.141.06
CD24a antigenBB5605741.57*1.331.12Cell proliferation
SRp20, splicing factor, arginine/serine-rich 3AV1353831.53*1.320.91mRNA splicing
WNK1 (protein kinase, lysine deficient 1)BI6922551.53*1.000.93Blood pressure
ATPase, Na+/K+ transporting, alpha 2 polypeptideBQ1759152.23*2.93*1.71*Nt uptake, K+ uptake
SRY-box containing gene 11BG0727390.961.82*0.95Transcription
Histone 1, H2afW910241.041.60*1.16Nucleosome structure
Upstream transcription factor 1AF4797731.53*1.55*1.45Transcription
Early B-cell factor 3AK0140581.131.54*0.76Transcription
RNA-binding region (RNP1, RRM) containing 2BB4368561.401.53*1.46Transcription
CDC28 protein kinase regulatory subunit 2NM_0254151.091.53*1.20Cell cycle
Procollagen, type III, alpha 1BG9688941.081.092.10*Cell adhesion
Surfeit gene 4AI7886231.201.231.83*Membrane protein
GABAA receptor, subunit alpha 6NM_0080681.060.57*0.92Synaptic transmission
ATPase, Na+/K+ transporting, alpha 2 polypeptideAI8451770.720.66*0.56*Nt uptake, K+ uptake
Kinesin family member 5ANM_0084471.040.800.53*Microtubule based transport
ADP-ribosylation factor 3NM_0074781.050.800.56*Protein transport
Contactin associated protein 1NM_0167820.960.960.57*Cell adhesion
Fibroblast growth factor 1BM9324510.860.950.59*Angiogenesis, cell proliferation
Growth arrest specific 7NM_0080880.890.890.59*Neurite outgrowth
Ca2+/calmodulin-dependent protein kinase II alphaX148361.040.690.59*Cell cycle, synaptic plasticity
K+/Cl co-transporter (KCC2/SLC12A5)AF3320641.130.900.62*Synaptic transmission
Glutamate receptor, ionotropic, NMDA1 (ζ1)NM_0081690.960.800.63*Synaptic transmission
Synaptotagmin 2AF2573041.021.000.64*Synaptic transmission
Fascin homolog 1, actin bundling proteinBE9520571.060.860.64*Actin binding
Potassium voltage-gated channel, beta member 2L489830.870.860.64*Ion transport
Protein tyrosine phosphatase, receptor type, FNM_0112130.981.030.65*Cell adhesion
Coronin, actin binding protein 1CAW5488370.970.940.65*Actin assembly
Chapsyn-110 [discs, large homolog 2 (DLG2)]BB6227671.290.800.65*Synaptic transmission
  • Genes with altered expression in male Pkbγ−/− mice (n=3) compared with Pkbγ+/+ animals at different time points during postnatal brain development.

    Nt, neurotransmitter.

  • * Significant changes (1.5 fold).