Table 1.

New Mad mutant sequences

AlleleLesionCodonDomainAlterationEffect*
Mad1 Missense90MH1Gln to LeuDominant negative
Mad5 Missense272MH2Arg to HisLoss of function (hypomorph)
Mad6 Missense272MH2Arg to HisLoss of function (hypomorph)
MadB65.3 Missense272MH2Arg to HisLoss of function (hypomorph)
Mad8 Missense358MH2Ser to LeuLoss of function (hypomorph)
Mad11 Missense410MH2Gly to AspLoss of function (hypomorph)
Mad7 Missense419MH2Val to MetLoss of function (null)