Table 2.

Human SMAD tumor alleles expressed in flies

AlleleLesionCodonDomainAlterationTumorReference
SMAD4100T Missense100MH1Arg to ThrPancreas Schutte et al., 1996
SMAD4130S Missense130MH1Pro to SerColorectal Thiagalingam et al., 1996
SMAD4493H Missense493MH2Asp to HisPancreas Hahn et al., 1996
SMAD4524ST Nonsense524MH2Cys to StopColorectal Riggins et al., 1996
SMAD2Δ344-358 Deletion344-358MH214aa deletionColorectal Riggins et al., 1996