Table 1.

In vitro analysis of early dorsal bud formation

Wild type (n)Cdh2−/− (n)Cdh2−/− + plasma (n)Cdh2−/− + S1P (n)Cdh2−/− + PTX + S1P (n)WT + PTX (n)
db20 (21)3 (18)5 (10)9 (14)2 (6)7 (10)
% db*95%17%50%64%33%70%
  • db, early dorsal bud formation.

  • * Percentage of explants that develop a dorsal bud in addition to a ventral bud.