Table 2.

Genes differentially expressed between control and Gata4T2del AVCs

RankProbe set IDGene symbolGene nameUniGene IDFold change
Downregulated genes
11418788_atTekEndothelial-specific receptor tyrosine kinaseMm.14313−1.6
21423213_atPlxnc1a,cPlexin C1Mm.256712−1.8
31434606_atErbb3a,cv-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)Mm.29023−2.1
41421811_atThbs1a,cThrombospondin 1Mm.4159−2.2
51426294_atHapln1Hyaluronan and proteoglycan link protein 1Mm.266790−1.8
61456144_atNav3Neuron navigator 3Mm.225050−1.8
71416342_atTncaTenascin CMm.980−2.0
81444403_atCbfa2t2hCore-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog (human) (Cbfa2t2h), mRNAMm.29914−1.5
91449303_atSesn3Sestrin 3Mm.227443−1.7
101422286_a_atTgifTG interacting factorMm.101034−2.2
111421908_a_atTcf12Transcription factor 12Mm.171615−1.6
121448293_atEbf1Early B-cell factor 1Mm.215971−1.5
131426295_atHapln 1Hyaluronan and proteoglycan link protein 1Mm.266790−1.9
141442019_at-16 days neonate cerebellum cDNA, RIKEN full-length enriched library, clone:9630033M11 product: unclassifiable, full insert sequenceMm.152121−2.7
151435727_s_atD15Ertd366eDNA segment, Chr 15, ERATO Doi 366, expressedMm.33207−1.5
161452366_at4732435N03RikRIKEN cDNA 4732435N03 geneMm.334569−2.6
171432029_a_atSmap 1Stromal membrane-associated protein 1Mm.329963−1.9
181434957_atCdonCell adhesion molecule-related/downregulated by oncogenesMm.80509−1.8
191434510_atPapss23′-phosphoadenosine 5′-phosphosulfate synthase 2Mm.203916−3.9
201437401_atIgf1bInsulin-like growth factor 1Mm.268521−2.0
211434413_at-Transcribed locusMm.380595−2.1
221451740_atPaip 1Polyadenylate binding protein-interacting protein 1Mm.132584−2.0
231439641_atLOC553090Hypothetical LOC553090-−2.4
241418120_atRbm8aRNA binding motif protein 8aMm.261972−1.5
251426862_at9130023F12RikRIKEN cDNA 9130023F12 geneMm.356580−1.7
261417625_s_atCmkor1Chemokine orphan receptor 1Mm.6522−2.3
271421917_atPdgfraPlatelet derived growth factor receptor, alpha polypeptideMm.221403−1.7
Upregulated genes
11449187_atPdgfaaPlatelet derived growth factor, alphaMm.26751.6
21439713_atItga1Integrin alpha 1-1.5
31423100_atFosFBJ osteosarcoma oncogeneMm.2465131.9
41426114_atHnrpabHeterogeneous nuclear ribonucleoprotein A/BMm.2808421.7
51421126_atRyr2Ryanodine receptor 2, cardiacMm.2398711.7
61433657_atA130092J06RikRIKEN cDNA A130092J06 geneMm.2504411.5
71415949_atCpeCarboxypeptidase EMm.313951.5
81419647_a_atler3Immediate early response 3Mm.256131.6
91456768_a_at---1.8
101430781_atAk7Adenylate kinase 7Mm.360061.6
111425196_a_atHint2Histidine triad nucleotide binding protein 2Mm.252851.5
121420991_atAnkrd1bAnkyrin repeat domain 1 (cardiac muscle)Mm.102791.8
131458917_at---1.9
141439518_at---1.8
151449897_a_atMtcp1Mature T-cell proliferation 1Mm.163661.5
161460519_a_atMettl5Methyltransferase like 5Mm.2686571.7
171447845_s_atVnn1Vanin 1Mm.271541.7
181445938_at5930427L02RikRIKEN cDNA 5930427L02 geneMm.3795231.7
191418486_atVnn1Vanin 1Mm.271541.5
201422529_s_atCasq2Calsequestrin 2Mm.153431.6
211429317_atQrsl1Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1Mm.59041.6
221417313_atLsm7LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)Mm.3791013.8
231451370_at-Adult male kidney cDNA, RIKEN full-length enriched library, clone:0610042I08 product:RNA component of mitochondrial RNAase P, 1, full insert sequenceMm.2891091.7
241430787_at2310050B05RikRIKEN cDNA 2310050B05 gene-1.6
251455251_atItga1Integrin alpha 1-1.6
261431248_at5031426D15RikRIKEN cDNA 5031426D15 gene-1.6
271426902_atCoq6Coenzyme Q6 homolog (yeast)Mm.2800621.6
281437904_atMGI:2387367Developmentally regulated RNA binding protein 1Mm.333102.1
291428960_at4933434I06RikRIKEN cDNA 4933434I06 geneMm.276581.5
301417150_atSlc6a4Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4Mm.3003182.2
311455227_atAadacl1Arylacetamide deacetylase-like 1Mm.245761.6
321434865_a_atExoc7Exocyst complex component 7Mm.225301.7
331435436_at-Transcribed locusMm.2348752.2
341417713_atEif2s2Eukaryotic translation initiation factor 2, subunit 2 (beta)Mm.3832181.7
351452840_at1500009L16RikRIKEN cDNA 1500009L16 geneMm.2711882.4
361440397_at---2.0
371430023_at5133400G04RikRIKEN cDNA 5133400G04 geneMm.1514981.6
381427263_atXistInactive X specific transcripts-1.9
391449146_atNotch4Notch gene homolog 4 (Drosophila)Mm.1738132.8
401436723_atFshprh1FSH primary response 1Mm.349031.6
  • Genes differentially expressed between between control (n=2) and mutant (n=4) were identified by SAM (Δ>0.4 and fold-change> 1.5) and ranked by the relative difference score.

  • a Differential expression validated by qRT-PCR (P<0.05).

  • b Differential expression failed validation by qRT-PCR (P>0.05).

  • c Differential expression validated by in situ hybridization.