Table 1.

Summary of the expression of FGF target genes in tail cultures in the absence (DMSO control) and presence of either the FGFR1 inhibitor SU5402 or the MAPK inhibitor U0126

Culture conditionPhase IPhase IIPhase IIIPhase inhibitorn
Lfng
2 hDMSO33392818
U012626393523
SU54028335812
3 hDMSO4040205
SU540228185540
4 hDMSO33333315
SU540210207040
6 hDMSO40303010
SU54026128217
Axin2
2 hDMSO333333021
SU540205108520
3 hDMSO304030010
SU540200010014
4 hDMSO33333303
SU54020001009
  • Percentage of tails in Phases I, II and III are given for each combination at 2, 3, 4 and 6 hours. For Axin2, which shows an abnormal expression pattern after inhibitor treatment (data not shown), an additional column (Phase inhibitor) is introduced.