Table 1.

Comparison of gene expression in the adrenal gland of heterozygous and homozygous Insm1^lacZ mutant mice

Gene symbol	Gene name	FC	P
Hormone processing and secretion
Akr1c18	Aldo-keto reductase family 1, member C18	−39.7	0.001
Pnmt ^*	Phenylethanolamine-N-methyltransferase	−28.1	0.001
Th ^*	Tyrosine hydroxylase	−6.7	0.001
Dbh ^*	Dopamine beta hydroxylase	−6.9	0.001
Chga ^*	Chromogranin A	−13.3	0.001
Chgb ^*	Chromogranin B	−8.7	0.001
Scg2	Secretogranin II	−4.0	0.001
Scg3	Secretogranin III	−4.1	0.001
Sgne1	Secretogranin V	−4.8	0.001
Slc18a1	Vesicular monoamine Transporter (VMAT1)	−4.2	0.001
Slc7a8	Cationic amino acid transporter (LAT2)	− 4.1	0.001
Transcription factors
Gata2	GATA binding protein 2	−3.4	0.001
Gata3 ^*	GATA binding protein 3	−3.4	0.001
Phox2a ^*	Paired-like homeobox 2a	−2.9	0.001
Phox2b ^*	Paired-like homeobox 2b	−1.9	0.001
Hand2 ^*	Hand2	−1.8	0.001
Mash1 ^*	Achaete-scute complex homolog-like 1 (Ascl 1)	2.6	0.001
Ebf1	Early B-cell factor 1	2.1	0.001
Other factors
Resp18	Regulated endocrine-specific protein 18	−10.5	0.001
Disp2	Dispatched homolog 2	−9.2	0.001
Sez612	Seizure related 6 homolog like 2	−4.2	0.001
Igf1	Insulin-like growth factor 1	4.5	0.001
Dkk2	Dickkopf homolog 2 (Xenopus laevis)	4.4	0.001
Nefl ^*	Neurofilament 68	2.1	0.001

Systematic analysis of gene expression in control and Insm1^lacZ/Insm1^lacZ mice using Affymetrix oligonucleotide microarrays. The average signal fold change is shown. We selected the following genes for display: (1) genes that are downregulated at least fourfold; (2) genes of known function during chromaffin cell development; (3) genes that were upregulated at least twofold.

FC, fold change.
↵* Also analyzed by immunohistochemistry or by in situ hybridization.