Table 1.

Ror2W749FLAG/W749FLAG spermatozoa are functional

Animal*Plugged superovulated femaleSpermatozoa motility (%)Spermatozoa concentration (million/ml)Progressive spermatozoa (%)IVF rate (%)Number of blastocysts/2-cell embryos (%)
B6D2F1 Yes 71 38.1 56 66/83 (79.5%) 64/66 (96.9%)
WT-1 No 71 29.6 49 23/87 (26.4%) 23/23 (100.0%)
WT-2 Yes 66 21.0 45 23/83 (27.7%) 22/23 (95.6%)
WT-3 Yes 73 55.5 54 55/109 (50.4%) 52/55 (94.5%)
KI-1 No 63 22.1 44 63/96 (65.6%) 62/63 (98.4%)
KI-2 No 74 25.1 58 61/106 (57.5%) 59/61 (96.7%)
KI-3 No 63 22.3 43 55/81 (67.9%) 53/55 (96.4%)
  • * Three-month-old males, homozygous mutant (KI) and wild-type (WT) littermates.

  • Two-cell embryos/fertilized oocytes.