Table 2.

Genes implicated in epidermal differentiation that are upregulated in the epidermis following 24-hour culture with EGF or KGF ligand

GeneControlKGFHBEGF
filaggrin09829
involucrin03824
loricrin022
keratin complex 2, basic, gene 6a035
keratin complex 2, basic, gene 6b02085
keratin complex, acidic, gene 1606470
S100a18065
S100a6096
transglutaminase 1, K polypeptide022
lectin, galactose binding, soluble 7032
small proline-rich protein 1A0106
small proline-rich protein 1B055
small proline-rich protein 2A01218
small proline-rich protein 3014425
  • Embryonic skin was cultured with BSA (control) (250 ng/ml), HBEGF (250 ng/ml) or KGF (250 ng/ml) for 24 hours and genomic transcript expression was profiled by microarray. Multiple genes involved in normal interfollicular keratinocyte differentiation and barrier formation are upregulated following HBEGF or KGF treatment. 0, baseline levels or no change; numbers, fold of baseline.