Blood vessel
- Vessel-derived angiocrine IGF1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
Highlighted Article: This study shows IGF1 is secreted directly from endothelial cells in an angiocrine manner to instruct proliferation of Meckel's cartilage, underpinning correct jaw growth and extension during development.
- Development of vascular regulation in the zebrafish embryo
Summary: Live imaging and genetic ablation experiments reveal the regulation of blood flow in early developing zebrafish cerebral vessels, and the role of pericytes and vascular smooth muscle cells in response to stimuli.
- VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels
Summary: NRP1 plays a dual role in retinal ganglion cells and in vascular endothelial cells to organise axons along the optic pathway between the mouse retina and diencephalon.
- Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus
Summary: The endochondral ossification of the malleus, an ossicle of the mouse inner ear, occurs around capillaries and is mediated by the AP-1 transcription factor Fosl1.