Cargo adaptor
- The Egalitarian binding partners Dynein light chain and Bicaudal-D act sequentially to link mRNA to the Dynein motor
Summary: An shRNA depletion strategy has uncovered the role of Dlc in the dimerization of Egl, further revealing a step-wise assembly pathway for building a localization-competent mRNP.
- Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells
Summary: Nuclear positioning in developing skeletal muscle cells is dependent on interactions between kinesin light chains and nesprins, which localize kinesin to the nuclear envelope.