Chondrocyte
- Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
Summary: Conditional deletion of genes that regulate intracellular cholesterol biosynthesis in mesenchymal cells or chondrocytes shows that precise regulation of biosynthesis is required for chondrocyte homeostasis and long bone growth.
- Blood vessel formation and function in bone
Summary: This Review discusses the roles of blood vessels in controlling developmental and regenerative bone formation and providing niche microenvironments for various cell types.
- Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae
Summary: The protocadherins Fat4 and Dchs1 promote proliferation in the developing mouse somites, independently of both the planar cell polarity pathway and the Yap/Taz Hippo effectors.
- Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration
Highlighted article: The analysis of zebrafish jawbone regeneration reveals important differences between how the skeleton is formed in the embryo and repaired in adults.
- FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth
Summary: Conditional ablation of Fgfr1 and Fgfr2 in the osteoblast lineage in mouse reveals a feed-forward loop controlling FGFR3 signaling in growth plate chondrocytes.
- Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
Summary: During bone formation in neonatal mice, chondrocytic expression of the receptor tyrosine kinase Ephrin B2 regulates cartilage degradation and subsequent osteoclastic destruction of the cartilage matrix.