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Chondrocyte

  • RESEARCH ARTICLE
    Zebrafish model for spondylo-megaepiphyseal-metaphyseal dysplasia reveals post-embryonic roles of Nkx3.2 in the skeleton
    Joanna Smeeton, Natasha Natarajan, Arati Naveen Kumar, Tetsuto Miyashita, Pranidhi Baddam, Peter Fabian, Daniel Graf , J. Gage Crump
    Development 2021 148: dev193409 doi: 10.1242/dev.193409 Published 25 January 2021

    Summary: Characterization of a zebrafish model of SMMD reveals that the transcription factor Nkx3.2 fine-tunes chondrocyte proliferation at skeletal joints versus endochondral growth plates by modulating stress-response and mTORC1 pathways.

  • TECHNIQUES AND RESOURCES
    A single cell transcriptional atlas of early synovial joint development
    Qin Bian, Yu-Hao Cheng, Jordan P. Wilson, Emily Y. Su, Dong Won Kim, Hong Wang, Sooyeon Yoo, Seth Blackshaw, Patrick Cahan
    Development 2020 147: dev185777 doi: 10.1242/dev.185777 Published 20 July 2020

    Summary: Defining the transcriptional programs of synovial joint cells in mouse development, including progenitors of tendon, ligament, synovium, meniscus, sheath, and permanent and transient chondrocytes, using single-cell RNA-seq.

  • RESEARCH ARTICLE
    Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
    Hidetoshi Tsushima, Yuning J. Tang, Vijitha Puviindran, Shu-Hsuan Claire Hsu, Puviindran Nadesan, Chunying Yu, Hongyuan Zhang, Anthony J. Mirando, Matthew J. Hilton, Benjamin A. Alman
    Development 2018 145: dev162396 doi: 10.1242/dev.162396 Published 9 July 2018

    Summary: Conditional deletion of genes that regulate intracellular cholesterol biosynthesis in mesenchymal cells or chondrocytes shows that precise regulation of biosynthesis is required for chondrocyte homeostasis and long bone growth.

  • REVIEW
    Blood vessel formation and function in bone
    Kishor K. Sivaraj, Ralf H. Adams
    Development 2016 143: 2706-2715; doi: 10.1242/dev.136861

    Summary: This Review discusses the roles of blood vessels in controlling developmental and regenerative bone formation and providing niche microenvironments for various cell types.

  • RESEARCH ARTICLE
    Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae
    Anna Kuta, Yaopan Mao, Tina Martin, Catia Ferreira de Sousa, Danielle Whiting, Sana Zakaria, Ivan Crespo-Enriquez, Philippa Evans, Bartosz Balczerski, Baljinder Mankoo, Kenneth D. Irvine, Philippa H. Francis-West
    Development 2016 143: 2367-2375; doi: 10.1242/dev.131037

    Summary: The protocadherins Fat4 and Dchs1 promote proliferation in the developing mouse somites, independently of both the planar cell polarity pathway and the Yap/Taz Hippo effectors.

  • STEM CELLS AND REGENERATION
    Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration
    Sandeep Paul, Simone Schindler, Dion Giovannone, Alexandra de Millo Terrazzani, Francesca V. Mariani, J. Gage Crump
    Development 2016 143: 2066-2076; doi: 10.1242/dev.131292

    Highlighted article: The analysis of zebrafish jawbone regeneration reveals important differences between how the skeleton is formed in the embryo and repaired in adults.

  • RESEARCH ARTICLE
    FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth
    Kannan Karuppaiah, Kai Yu, Joohyun Lim, Jianquan Chen, Craig Smith, Fanxin Long, David M. Ornitz
    Development 2016 143: 1811-1822; doi: 10.1242/dev.131722

    Summary: Conditional ablation of Fgfr1 and Fgfr2 in the osteoblast lineage in mouse reveals a feed-forward loop controlling FGFR3 signaling in growth plate chondrocytes.

  • RESEARCH ARTICLE
    Chondrocytic ephrin B2 promotes cartilage destruction by osteoclasts in endochondral ossification
    Stephen Tonna, Ingrid J. Poulton, Farzin Taykar, Patricia W. M. Ho, Brett Tonkin, Blessing Crimeen-Irwin, Liliana Tatarczuch, Narelle E. McGregor, Eleanor J. Mackie, T. John Martin, Natalie A. Sims
    Development 2016 143: 648-657; doi: 10.1242/dev.125625

    Summary: During bone formation in neonatal mice, chondrocytic expression of the receptor tyrosine kinase Ephrin B2 regulates cartilage degradation and subsequent osteoclastic destruction of the cartilage matrix.

  • RESEARCH ARTICLES
    mTORC1 signaling controls mammalian skeletal growth through stimulation of protein synthesis
    Jianquan Chen, Fanxin Long
    Development 2014 141: 2848-2854; doi: 10.1242/dev.108811
  • STEM CELLS AND REGENERATION
    Specification of chondrocytes and cartilage tissues from embryonic stem cells
    April M. Craft, Nazish Ahmed, Jason S. Rockel, Gurpreet S. Baht, Benjamin A. Alman, Rita A. Kandel, Agamemnon E. Grigoriadis, Gordon M. Keller
    Development 2013 140: 2597-2610; doi: 10.1242/dev.087890

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