Chondrogenesis
- Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling
Summary: Cell sorting identifies limb bud mesenchymal progenitors (LMPs) with distinct molecular signatures and differential dependence on morphogen signaling. Specifically, two immature LMP populations with strong chondrogenic differentiation potential are identified.
- SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis
Summary: SOX9 directly upregulates genes specifically expressed in precartilaginous condensations and well-known early-cartilage markers, but only partially contributes to the initiation of chromatin remodeling at precartilage and early-cartilage loci.
- The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells
Summary: This study identified a chondrocyte repertoire of lncRNAs and discovered that ROCR (regulator of chondrogenesis RNA) is important for MSC chondrogenesis and cartilage gene expression by promoting the expression of SOX9.
- Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl
Summary: A unique transcriptional program that regulates the coordination of positional information and tissue differentiation in regenerating salamander limbs and tails .
- Osteocrin, a peptide secreted from the heart and other tissues, contributes to cranial osteogenesis and chondrogenesis in zebrafish
Summary: Osteocrin functions as a hormone that controls remote bone/cartilage formation in zebrafish by modulating CNP-dependent nuclear export of the transcriptional cofactors Yap1 and Wwtr1.
- PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud
Summary: In the developing mouse limb bud, loss of the arginine methyltransferase PRMT5 leads to elevated BMP4 activity, precocious progenitor differentiation and widespread apoptosis.
- A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation
Summary: This Review article discusses how signaling molecules, mechanical signals and morphological cell features are integrated to regulate chondrogenesis and bone development.