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Congenital heart disease

  • PRIMER
    The developing heart: from The Wizard of Oz to congenital heart disease
    Benoit G. Bruneau
    Development 2020 147: dev194233 doi: 10.1242/dev.194233 Published 21 October 2020

    Summary: This Primer summarizes discoveries in heart development that have led to a revolution in understanding organogenesis and gene regulation, and how this is being applied to investigating regeneration of the diseased heart.

  • RESEARCH ARTICLE
    Gene-environment interaction impacts on heart development and embryo survival
    Julie L. M. Moreau, Scott Kesteven, Ella M. M. A. Martin, Kin S. Lau, Michelle X. Yam, Victoria C. O'Reilly, Gonzalo del Monte-Nieto, Antonio Baldini, Michael P. Feneley, Anne M. Moon, Richard P. Harvey, Duncan B. Sparrow, Gavin Chapman, Sally L. Dunwoodie
    Development 2019 146: dev172957 doi: 10.1242/dev.172957 Published 20 February 2019

    Highlighted Article: Studies using Nkx2-5, Tbx1 and Fgfr1/Fgfr2 mutant mice reveal how a genetic predisposition to developing a heart defect can combine with short-term gestational hypoxia to cause defects and foetal death.

  • RESEARCH REPORT
    WDR5 regulates left-right patterning via chromatin-dependent and -independent functions
    Saurabh S. Kulkarni, Mustafa K. Khokha
    Development 2018 145: dev159889 doi: 10.1242/dev.159889 Published 28 November 2018

    Highlighted Article: The candidate congenital heart disease gene WDR5 is essential for left-right patterning via its role in ciliogenesis. WDR5, a chromatin modifier, regulates transcription of foxj1 but also has a nonchromatin role at the ciliary base.

  • RESEARCH ARTICLE
    Unique developmental trajectories and genetic regulation of ventricular and outflow tract progenitors in the zebrafish second heart field
    Noelle Paffett-Lugassy, Natasha Novikov, Spencer Jeffrey, Maryline Abrial, Burcu Guner-Ataman, Srinivasan Sakthivel, Caroline E. Burns, C. Geoffrey Burns
    Development 2017 144: 4616-4624; doi: 10.1242/dev.153411

    Summary: This study uncovers novel aspects of head muscle and heart development in zebrafish, information that will be crucial for deciphering the cellular mechanisms underlying zebrafish models of human congenital disorders.

  • RESEARCH ARTICLES
    The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry
    S. Joseph Endicott, Basudha Basu, Mustafa Khokha, Martina Brueckner
    Development 2015 142: 4068-4079; doi: 10.1242/dev.126953

    Highlighted article: Nek2 regulates both cilia biogenesis, by controlling centriole dynamics, and cilia resorption, via its interaction with Nup98, in the Xenopus left-right organizer.

  • RESEARCH ARTICLES
    Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development
    Kerry M. Dorr, Nirav M. Amin, Lauren M. Kuchenbrod, Hanna Labiner, Marta S. Charpentier, Larysa H. Pevny, Andy Wessels, Frank L. Conlon
    Development 2015 142: 2037-2047; doi: 10.1242/dev.119107

    Summary: Cardiac-specific deletion of the para-zinc-finger protein CASZ1 in mouse embryos leads to significant heart defects associated with impaired cardiomyocyte proliferation.

  • RESEARCH ARTICLES
    Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity
    Stephen Sojka, Nirav M. Amin, Devin Gibbs, Kathleen S. Christine, Marta S. Charpentier, Frank L. Conlon
    Development 2014 141: 3040-3049; doi: 10.1242/dev.106518
  • DEVELOPMENT AND DISEASE
    Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling
    Eon Joo Park, Lisa A. Ogden, Amy Talbot, Sylvia Evans, Chen-Leng Cai, Brian L. Black, Deborah U. Frank, Anne M. Moon
    Development 2006 133: 2419-2433; doi: 10.1242/dev.02367

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