CXCR4
- COUP-TFI mitotically regulates production and migration of dentate granule cells and modulates hippocampal Cxcr4 expression
Summary: Mice mutant for the COUP-TFI transcription factor show severe growth defects in the hippocampal dentate gyrus, due to impaired proliferation, precocious differentiation and abnormal migration of granule cells.
- Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons
Summary: The spinal motor neuron-specifying LIM complex controls ventral motor axonal projection by activating the expression of STAM1, which in turn regulates the chemokine receptor CXCR4.
- Disruption of CXCR4 signaling in pharyngeal neural crest cells causes DiGeorge syndrome-like malformations
Summary: SDF1/CXCR4 signaling lies downstream of Tbx1 during pharyngeal neural crest development, and inactivating CXCR4 causes defects that phenocopy the human DiGeorge syndrome.