Ependymal cells
- CAMSAP3 is required for mTORC1-dependent ependymal cell growth and lateral ventricle shaping in mouse brains
Highlighted Article: CAMSAP3, which mediates non-centrosomal microtubule assembly, is required for mTORC1-dependent maturation of ependymal cells at the neocortex of developing mouse brains. Loss of CAMSAP3 causes deformation of the lateral ventricles.
- A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice
Summary: Ccdc39-deficient ependymal cells exhibit abundant short, thin cilia that are incapable of creating the rhythmic beating pattern necessary for cerebrospinal fluid flow in the perinatal mouse brain.