Fat
- Planar cell polarity: two genetic systems use one mechanism to read gradients
Summary: The key molecules responsible for planar cell polarity form bridges that span between neighbouring cells. Gradients across the tissue cause these bridges to be asymmetrically localised within each cell.
- Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching
Highlighted article: In mice, kidney morphogenesis and size of the nephron progenitor pool are regulated by Fat4-Dchs1 signaling between stromal cells and nephron progenitors, independently of YAP.