fate map
- Developmental analyses of mouse embryos and adults using a non-overlapping tracing system for all three germ layers
Highlighted Article: We have developed a new transgenic technique for simultaneous labelling of all three germ layers in mice that overcomes the difficulties of conventional single-gene tracing systems in precision lineage tracing.
- Mapping cell migrations and fates in a gastruloid model to the human primitive streak
Highlighted Article: Comparative analysis of human gastruloids along with recording of cell migrations enables the piecing together of part of a rudimentary fate map for the human primitive streak.
- A mesodermal fate map for adipose tissue
Highlighted Article: Embryonic cell lineage tracing of adipose tissue reveals that perigonadal fat arises from distinct mesodermal subcompartments in males and females, and that <50% of interscapular brown fat arises from central dermomyotome.
- A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons
Summary: A novel boundary that subdivides the mouse mesodiencephalic floor plate into two microdomains, each giving rise to distinct types of neurons, is identified.