Fgf
- Pinhead signaling regulates mesoderm heterogeneity via the FGF receptor-dependent pathway
Summary: Xenopus Pinhead is a secreted cystine-knot protein that functions in a positive feedback loop with FGF to activate Erk signaling and induce mesoderm.
- Fgf-driven Tbx protein activities directly induce myf5 and myod to initiate zebrafish myogenesis
Highlighted Article: Tbx16 and Tbxta activate myf5 and myod directly during the earliest myogenesis in zebrafish, and Fgf signalling acts through Tbx16 to drive myogenesis in trunk but not tail.
- Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development
Highlighted Article: Myh3 mouse alleles reveal that MyHC-embryonic is crucial for skeletal muscle development and adult Myh3 null mice exhibit scoliosis, a phenotype seen in congenital contracture syndromes.
- Pineal progenitors originate from a non-neural territory limited by FGF signalling
Highlighted Article: Gene expression and fate mapping/lineage tracing in zebrafish reveals that the pineal organ develops from the non-neural pre-placodal ectoderm under the control of FGF signalling.
- N-cadherin stabilises neural identity by dampening anti-neural signals
Summary: As pluripotent cells undergo neural differentiation they swap E-cadherin for N-cadherin. This switch in adhesion molecules modulates signalling in order to facilitate the differentiation process.
- FGF signaling patterns cell fate at the interface between tendon and bone
Summary: FGF signaling is essential in establishing the graded transitional tissue of the tendon-bone attachment unit by regulating cell fate decisions and the development of Scx+/Sox9+ cells.
- Migrating cells control morphogenesis of substratum serving as track to promote directional movement of the collective
Summary: Collectively migrating cells not only respond to extrinsic molecular cues and surrounding topology, but can also physically modify the morphogenesis of their tissue substrate.
- A dual function of FGF signaling in Xenopus left-right axis formation
Summary: FGF signaling induces and patterns the frog left-right organizer in the early gastrula and regulates the morphogenesis of the flow sensor following specification of the precursor tissue.
- Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea
Summary: Wnt proteins from the epithelium control the formation of mouse airway cartilage and basal cells through crosstalk with Fgf signaling.
- Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity
Summary: During mouse limb morphogenesis, Wnt5a plays both instructive and permissive roles in regulating planar cell polarity by orienting PCP itself, and by allowing apical ectoderm ridge-derived Fgfs to orient PCP.