Germ cell
- Loss of the E2 SUMO-conjugating enzyme Ube2i in oocytes during ovarian folliculogenesis causes infertility in mice
Summary: Conditional deletion of the E2 SUMO-conjugating enzyme in mouse oocytes causes female infertility as a result of compound defects in ovarian follicle development and oocyte meiotic maturation and progression.
- Zebrafish prmt5 arginine methyltransferase is essential for germ cell development
Summary: Prmt5 apparently controls germ cell development by catalyzing arginine methylation of the germline-specific proteins Zili and Vasa.
- Pgc suppresses the zygotically acting RNA decay pathway to protect germ plasm RNAs in the Drosophila embryo
Summary: The Drosophila Pgc protein ensures proper primordial germ cell development by repressing transcription of miRNA genes and contributing to the maintenance of germ plasm integrity during the establishment of the germ cell fate.
- Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis
Summary: Bucky ball is essential for germ plasm assembly in zebrafish. It binds Kinesin-1, which promotes microtubule reorganisation after egg activation and is required for Bucky ball activity.