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Germ plasm

  • RESEARCH ARTICLE
    Pgc suppresses the zygotically acting RNA decay pathway to protect germ plasm RNAs in the Drosophila embryo
    Kazuko Hanyu-Nakamura, Kazuki Matsuda, Stephen M. Cohen, Akira Nakamura
    Development 2019 146: dev167056 doi: 10.1242/dev.167056 Published 4 April 2019

    Summary: The Drosophila Pgc protein ensures proper primordial germ cell development by repressing transcription of miRNA genes and contributing to the maintenance of germ plasm integrity during the establishment of the germ cell fate.

  • RESEARCH ARTICLE
    Distinct cis-acting elements mediate targeting and clustering of Drosophila polar granule mRNAs
    Whitby V. I. Eagle, Daniel K. Yeboah-Kordieh, Matthew G. Niepielko, Elizabeth R. Gavis
    Development 2018 145: dev164657 doi: 10.1242/dev.164657 Published 22 November 2018

    Summary: The accumulation of Drosophila germline mRNAs within polar granules is controlled by complex 3′UTR localization signals with distinct sub-elements that target mRNAs to the granules and promote mRNA clustering within them.

  • RESEARCH ARTICLE
    Modulation of F-actin dynamics by maternal Mid1ip1L controls germ plasm aggregation and furrow recruitment in the zebrafish embryo
    Celeste Eno, Francisco Pelegri
    Development 2018 145: dev156596 doi: 10.1242/dev.156596 Published 17 May 2018

    Summary: The cytoskeletal regulator Mid1ip1L is required in the early zebrafish embryo for F-actin dynamics and cortical contractions that modulate and facilitate germ plasm ribonucleoparticle aggregation.

  • RESEARCH ARTICLE
    Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo
    Celeste Eno, Timothy Gomez, Diane C. Slusarski, Francisco Pelegri
    Development 2018 145: dev156604 doi: 10.1242/dev.156604 Published 17 May 2018

    Summary: During early cleavage stages, Nebel is required for calcium store enrichment at the furrow, with the reduced calcium release in nebel mutants disrupting the medial-to-distal enrichment of germ plasm RNPs and microtubule arrays.

  • RESEARCH ARTICLE
    A novel role for sox7 in Xenopus early primordial germ cell development: mining the PGC transcriptome
    Amanda M. Butler, Dawn A. Owens, Lingyu Wang, Mary Lou King
    Development 2018 145: dev155978 doi: 10.1242/dev.155978 Published 8 January 2018

    Summary: RNA-sequencing and genetic manipulation of Xenopus laevis PGCs reveal novel roles for sox7 and pou5f3.3 in PGC development and a high degree of conservation between the Xenopus and human PGC transcriptomes. 

  • RESEARCH ARTICLE
    Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis
    Philip D. Campbell, Amanda E. Heim, Mordechai Z. Smith, Florence L. Marlow
    Development 2015 142: 2996-3008; doi: 10.1242/dev.124586

    Summary: Bucky ball is essential for germ plasm assembly in zebrafish. It binds Kinesin-1, which promotes microtubule reorganisation after egg activation and is required for Bucky ball activity.

  • HYPOTHESIS
    Primordial germ cells: the first cell lineage or the last cells standing?
    Andrew D. Johnson, Ramiro Alberio
    Development 2015 142: 2730-2739; doi: 10.1242/dev.113993

    Summary: In this Hypothesis article, Johnson and Alberio propose that the determinative mechanisms for PGC specification in most model systems evolved to promote speciation and evolvability, not to maintain the germ line.

  • STEM CELLS AND REGENERATION
    Stochastic specification of primordial germ cells from mesoderm precursors in axolotl embryos
    Jodie Chatfield, Marie-Anne O'Reilly, Rosemary F. Bachvarova, Zoltan Ferjentsik, Catherine Redwood, Maggie Walmsley, Roger Patient, Mathew Loose, Andrew D. Johnson
    Development 2014 141: 2429-2440; doi: 10.1242/dev.105346

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