Heart development
- Cohort-based multiscale analysis of hemodynamic-driven growth and remodeling of the embryonic pharyngeal arch arteries
Highlighted Article: Quantitative in vivo measurements and computational simulations have enabled the development of analytical tools necessary to identify distinct relationships between hemodynamic parameters and the rapidly morphing pharyngeal arch manifold.
- In vivo analysis of cardiomyocyte proliferation during trabeculation
Summary: Live imaging in zebrafish shows that cardiomyocyte division is preceded by sarcomere disassembly and changes in cell shape and volume, with distinct signaling pathways controlling proliferation of compact and trabecular cardiomyocytes.
- The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish
Summary: Investigation of Wwtr1 in zebrafish heart development reveals its role in compact wall maturation and trabeculation, as well as in modulation of the cardiomyocyte actomyosin network and cell-cell junctions.
- Heart morphogenesis gene regulatory networks revealed by temporal expression analysis
Summary: Transcriptome profiling during zebrafish heart looping reveals novel and evolutionarily conserved gene regulatory networks and cohorts of genes with shared temporal and spatial regulation.
- Rebuilding a broken heart: lessons from developmental and regenerative biology
Summary: This Meeting Review summarises the findings presented at the 2016 Weinstein Cardiovascular Development Conference, highlighting the range of research currently being applied to study human cardiac diseases.
- Gestational stress induces the unfolded protein response, resulting in heart defects
Highlighted article: Short-term gestational hypoxia in developing mouse embryos induces common types of heart defects by activating the unfolded protein response.
- Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress
Summary: Regulation of the Nppa-Nppb cluster in normal and stressed hearts involves the concerted action of multiple enhancers and epigenetic changes distributed across a structurally rigid regulatory domain.
- Multicolor mapping of the cardiomyocyte proliferation dynamics that construct the atrium
Summary: Lineage tracing of cardiomyocytes in the zebrafish heart reveal their proliferation dynamics and fate decisions, and distinguish atrial and ventricular morphogenesis at the cellular level.
- MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1
Summary: In the developing mouse anterior second heart field, the transcription factor MEF2C directly controls expression of the Nodal co-receptor Cripto to regulate outflow tract alignment.
- KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
Highlighted article: Cardiac-specific depletion of the H3K4 methyltransferase KMT2D causes dysregulation of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling.