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Histone methylation

  • RESEARCH ARTICLE
    C. elegans establishes germline versus soma by balancing inherited histone methylation
    Brandon S. Carpenter, Teresa W. Lee, Caroline F. Plott, Juan D. Rodriguez, Jovan S. Brockett, Dexter A. Myrick, David J. Katz
    Development 2021 : dev.196600 doi: 10.1242/dev.196600 Published 18 January 2021
  • RESEARCH ARTICLE
    The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology
    Karl B. Shpargel, Cassidy L. Mangini, Guojia Xie, Kai Ge, Terry Magnuson
    Development 2020 147: dev187997 doi: 10.1242/dev.187997 Published 17 July 2020

    Summary: Chromatin-modifying enzymes are mutated in a wide array of craniofacial disorders. This study contrasts KMT2D and UTX neural crest differentiation function as sources of variation in facial gestalt for Kabuki syndrome.

  • RESEARCH ARTICLE
    CXXC finger protein 1-mediated histone H3 lysine-4 trimethylation is essential for proper meiotic crossover formation in mice
    Yu Jiang, Hui-Ying Zhang, Zhen Lin, Ye-Zhang Zhu, Chao Yu, Qian-Qian Sha, Ming-Han Tong, Li Shen, Heng-Yu Fan
    Development 2020 147: dev183764 doi: 10.1242/dev.183764 Published 17 March 2020

    Summary: Conditional knockout of Cxxc1 in mouse pre-meiotic germ cells led to a decrease in H3K4me3, dysregulation of crossover formation and meiotic arrest, revealing an essential role for CXXC1 in spermatogenesis and oogenesis.

  • RESEARCH ARTICLE
    EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells
    Le Zhang, Sandrine Ettou, Myda Khalid, Mary Taglienti, Dhawal Jain, Youngsook L. Jung, Catherine Seager, Yongqing Liu, Kar-Hui Ng, Peter J. Park, Jordan A. Kreidberg
    Development 2018 145: dev157149 doi: 10.1242/dev.157149 Published 18 July 2018

    Summary: Conditional inactivation of the polycomb gene Eed in nephron progenitor cells results in their premature loss and prevents normal nephron differentiation beyond the S-shaped tubule stage.

  • RESEARCH ARTICLE
    Setd1b, encoding a histone 3 lysine 4 methyltransferase, is a maternal effect gene required for the oogenic gene expression program
    David Brici, Qinyu Zhang, Susanne Reinhardt, Andreas Dahl, Hella Hartmann, Kerstin Schmidt, Neha Goveas, Jiahao Huang, Lenka Gahurova, Gavin Kelsey, Konstantinos Anastassiadis, A. Francis Stewart, Andrea Kranz
    Development 2017 144: 2606-2617; doi: 10.1242/dev.143347

    Highlighted article: Oocyte-specific knockout of Setd1b in mouse disrupts the zona pellucida, metabolic processes and zygote morphology, identifying Setd1b as a key regulator of oocyte development.

  • RESEARCH ARTICLE
    The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryos
    Angeline Eymery, Zichuan Liu, Evgeniy A. Ozonov, Michael B. Stadler, Antoine H. F. M. Peters
    Development 2016 143: 2767-2779; doi: 10.1242/dev.132746

    Highlighted article: The H3K9 methyltransferase Setdb1 is required during mouse oogenesis to control gene expression, restrain expression of endogenous retroviruses and enable successful progression through meiosis and mitosis.

  • RESEARCH REPORT
    Chromatin condensation of Xist genomic loci during oogenesis in mice
    Atsushi Fukuda, Atsushi Mitani, Toshiyuki Miyashita, Akihiro Umezawa, Hidenori Akutsu
    Development 2015 142: 4049-4055; doi: 10.1242/dev.127308

    Summary: The analysis of chromatin state and H3K9me3 levels in mouse oocytes and early embryos provides insights into the dynamics of Xist repression and activation during early development and reprogramming.

  • RESEARCH ARTICLES
    Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature
    Paul Delgado-OlguĂ­n, Lan T. Dang, Daniel He, Sean Thomas, Lijun Chi, Tatyana Sukonnik, Nadiya Khyzha, Marc-Werner Dobenecker, Jason E. Fish, Benoit G. Bruneau
    Development 2014 141: 4610-4617; doi: 10.1242/dev.112607
  • STEM CELLS AND REGENERATION
    Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant
    Sergei Denissov, Helmut Hofemeister, Hendrik Marks, Andrea Kranz, Giovanni Ciotta, Sukhdeep Singh, Konstantinos Anastassiadis, Hendrik G. Stunnenberg, A. Francis Stewart
    Development 2014 141: 526-537; doi: 10.1242/dev.102681
  • RESEARCH ARTICLES
    The trithorax group proteins Kismet and ASH1 promote H3K36 dimethylation to counteract Polycomb group repression in Drosophila
    Kristel M. Dorighi, John W. Tamkun
    Development 2013 140: 4182-4192; doi: 10.1242/dev.095786

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