Histone modifications
- Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors
Highlighted Article: A FACS-based method for sorting different cell types and their ChIP-seq have provided an in vivo dataset that reveals dynamic histone modifications during neuronal differentiation in Drosophila.
- Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis
Summary: FabLEM, an endogenous labeling technique that uses modification-specific antigen-binding fragments, is used to examine changes in histone modification levels and transcription during zygotic genome activation in live zebrafish embryos.
- Mapping chromatin modifications at the single cell level
Summary: This Review highlights technical advances in single cell measurements of chromatin modifications, describing how these methods can be used to connect chromatin and gene expression, classify cell types, and study development and disease.