Hydrocephalus
- ZFP423 regulates early patterning and multiciliogenesis in the hindbrain choroid plexus
Summary: The zinc-finger protein 423, a transcription factor and protein-protein interaction hub, is identified as a master gene in hindbrain choroid plexus patterning and multiciliogenesis.
- The FOXJ1 target Cfap206 is required for sperm motility, mucociliary clearance of the airways and brain development
Summary: Evolutionarily conserved CFAP206 modulates ciliary beat frequency in multiciliated cells in Xenopus and mouse, and is required for radial spoke arrangement in mouse sperm flagella.
- A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice
Summary: Ccdc39-deficient ependymal cells exhibit abundant short, thin cilia that are incapable of creating the rhythmic beating pattern necessary for cerebrospinal fluid flow in the perinatal mouse brain.
- mTORC1 signaling and primary cilia are required for brain ventricle morphogenesis
Highlighted article: Primary cilia regulate ventricle morphogenesis in mice by modulating the mTORC1 pathway, highlighting a new role for mTOR signalling during brain development.
- Functional antagonism of voltage-gated K+ channel α-subunits in the developing brain ventricular system
Summary: Voltage-gated K+ channels establish a balance between cell proliferation and barrier properties in the neuroepithelium that lines the ventricles during development of the zebrafish brain ventricular system.