Insulin
- Growth control through regulation of insulin signalling by nutrition-activated steroid hormone in Drosophila
Summary: Nutrition regulates conversion of the steroid hormone ecdysone to 20-hydroxyecdysone, which, in turn, regulates insulin signalling and growth via insulin-producing cells in the brain and via the trachea.
- Hormonal control of growth in the wing imaginal disks of Junonia coenia: the relative contributions of insulin and ecdysone
Summary: In this species of butterfly, insulin primarily stimulates cytoplasmic growth and an increase in cell size, whereas ecdysone stimulates growth by increasing cell numbers through DNA synthesis and mitosis.
- Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila
Summary: Glycogen metabolism is regulated in a tissue-specific manner, independently of the glucagon homolog Akh, to maintain trehalose levels under starvation conditions in Drosophila.
- Cell dynamics underlying oriented growth of the Drosophila wing imaginal disc
Summary: Identification of a requirement for 20-hydroxyecdysone in tissue patterning leads to the discovery that dynamic cell rearrangements and shape changes contribute to oriented tissue growth in the Drosophila wing disc.
- Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues
Summary: Proper differentiation of somatic cyst stem cells as they move away from their niche requires an increase in PI3K/Tor signaling, downstream of Insulin receptor activation.
- glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
HIGHLIGHTED ARTICLE: Peptides derived from the glucagon gene are necessary for α to β cell fate switching during pancreatic islet regeneration in zebrafish.
- Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis
Summary: Inactivation of the Bicc1 gene, which is associated with kidney displasia in humans, causes pancreatic endocrine differentiation defects leading to cyst formation.