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Insulin

  • RESEARCH ARTICLE
    Drosophila Activin signaling promotes muscle growth through InR/TORC1-dependent and -independent processes
    Myung-Jun Kim, Michael B. O'Connor
    Development 2021 148: dev190868 doi: 10.1242/dev.190868 Published 10 January 2021

    Summary: The Activin branch of the TGF-β superfamily regulates Drosophila larval body wall muscle size in all three spatial dimensions through differential control of sarcomeric building block production and assembly.

  • RESEARCH ARTICLE
    Growth control through regulation of insulin signalling by nutrition-activated steroid hormone in Drosophila
    Kurt Buhler, Jason Clements, Mattias Winant, Lenz Bolckmans, Veerle Vulsteke, Patrick Callaerts
    Development 2018 145: dev165654 doi: 10.1242/dev.165654 Published 2 November 2018

    Summary: Nutrition regulates conversion of the steroid hormone ecdysone to 20-hydroxyecdysone, which, in turn, regulates insulin signalling and growth via insulin-producing cells in the brain and via the trachea.

  • RESEARCH ARTICLE
    Hormonal control of growth in the wing imaginal disks of Junonia coenia: the relative contributions of insulin and ecdysone
    H. Frederik Nijhout, Emily Laub, Laura W. Grunert
    Development 2018 145: dev160101 doi: 10.1242/dev.160101 Published 19 March 2018

    Summary: In this species of butterfly, insulin primarily stimulates cytoplasmic growth and an increase in cell size, whereas ecdysone stimulates growth by increasing cell numbers through DNA synthesis and mitosis.

  • RESEARCH ARTICLE
    Fat body glycogen serves as a metabolic safeguard for the maintenance of sugar levels in Drosophila
    Takayuki Yamada, Okiko Habara, Hitomi Kubo, Takashi Nishimura
    Development 2018 145: dev158865 doi: 10.1242/dev.158865 Published 14 March 2018

    Summary: Glycogen metabolism is regulated in a tissue-specific manner, independently of the glucagon homolog Akh, to maintain trehalose levels under starvation conditions in Drosophila.

  • RESEARCH ARTICLE
    Cell dynamics underlying oriented growth of the Drosophila wing imaginal disc
    Natalie A. Dye, Marko Popović, Stephanie Spannl, Raphaël Etournay, Dagmar Kainmüller, Suhrid Ghosh, Eugene W. Myers, Frank Jülicher, Suzanne Eaton
    Development 2017 144: 4406-4421; doi: 10.1242/dev.155069

    Summary: Identification of a requirement for 20-hydroxyecdysone in tissue patterning leads to the discovery that dynamic cell rearrangements and shape changes contribute to oriented tissue growth in the Drosophila wing disc.

  • STEM CELLS AND REGENERATION
    Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues
    Marc Amoyel, Kenzo-Hugo Hillion, Shally R. Margolis, Erika A. Bach
    Development 2016 143: 3914-3925; doi: 10.1242/dev.139782

    Summary: Proper differentiation of somatic cyst stem cells as they move away from their niche requires an increase in PI3K/Tor signaling, downstream of Insulin receptor activation.

  • STEM CELLS AND REGENERATION
    glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
    Lihua Ye, Morgan A. Robertson, Daniel Hesselson, Didier Y. R. Stainier, Ryan M. Anderson
    Development 2015 142: 1407-1417; doi: 10.1242/dev.117911

    HIGHLIGHTED ARTICLE: Peptides derived from the glucagon gene are necessary for α to β cell fate switching during pancreatic islet regeneration in zebrafish.

  • STEM CELLS AND REGENERATION
    Bicaudal C1 promotes pancreatic NEUROG3+ endocrine progenitor differentiation and ductal morphogenesis
    Laurence A. Lemaire, Joan Goulley, Yung Hae Kim, Solenne Carat, Patrick Jacquemin, Jacques Rougemont, Daniel B. Constam, Anne Grapin-Botton
    Development 2015 142: 858-870; doi: 10.1242/dev.114611

    Summary: Inactivation of the Bicc1 gene, which is associated with kidney displasia in humans, causes pancreatic endocrine differentiation defects leading to cyst formation.

  • RESEARCH ARTICLES
    A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication
    Wesley L. Hung, Ying Wang, Jyothsna Chitturi, Mei Zhen
    Development 2014 141: 1767-1779; doi: 10.1242/dev.103846
  • REVIEWS
    Nutritional regulation of stem and progenitor cells in Drosophila
    Jiwon Shim, Shubha Gururaja-Rao, Utpal Banerjee
    Development 2013 140: 4647-4656; doi: 10.1242/dev.079087

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