Kinesin-1
- Dual control of Kinesin-1 recruitment to microtubules by Ensconsin in Drosophila neuroblasts and oocytes
Summary: A combination of genetic studies with rescue constructs and in vitro experiments reveal that Drosophila Ensconsin recruits but also stimulates Kinesin-1 affinity for microtubules.
- Nesprins and opposing microtubule motors generate a point force that drives directional nuclear motion in migrating neurons
Highlighted Article: During migration of mouse cerebellar neurons, microtubules dynamically bind to nesprins in the nuclear envelope via kinesin-1 and dynein, and induce sharpening, rotation and translocation of the nucleus independently of actin.
- Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis
Summary: Bucky ball is essential for germ plasm assembly in zebrafish. It binds Kinesin-1, which promotes microtubule reorganisation after egg activation and is required for Bucky ball activity.
- Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells
Summary: Nuclear positioning in developing skeletal muscle cells is dependent on interactions between kinesin light chains and nesprins, which localize kinesin to the nuclear envelope.