KMT2D
- The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology
Summary: Chromatin-modifying enzymes are mutated in a wide array of craniofacial disorders. This study contrasts KMT2D and UTX neural crest differentiation function as sources of variation in facial gestalt for Kabuki syndrome.
- KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
Highlighted article: Cardiac-specific depletion of the H3K4 methyltransferase KMT2D causes dysregulation of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling.