LHX2
- Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon
Summary: The cortical hem, a telencephalic organizer that induces the hippocampus, is positionally restricted by the transcription factor FOXG1 acting directly and also by positively regulating LHX2.
- The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis
Summary: Ldb1 and Ldb2 have both overlapping and specific functions in mouse retinal development, specifically in maintaining the pool of retinal progenitors and for the generation of early-born photoreceptors.
- Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth
Summary: Loss of LHX2 replicates a subset of the phenotypes seen in embryos with reduced NF-κB signaling, while exogenous TGFβ2 can rescue this effect in Lhx2 knockout skin explants.