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LHX2

  • RESEARCH REPORT
    An evolutionarily conserved Lhx2-Ldb1 interaction regulates the acquisition of hippocampal cell fate and regional identity
    Veena Kinare, Archana Iyer, Hari Padmanabhan, Geeta Godbole, Tooba Khan, Zeba Khatri, Upasana Maheshwari, Bhavana Muralidharan, Shubha Tole
    Development 2020 147: dev187856 doi: 10.1242/dev.187856 Published 19 October 2020

    Summary: Similar to an Apterous-Chip mechanism that patterns the Drosophila wing blade, the interaction between mammalian orthologs Lhx2 and Ldb1 regulates multiple aspects of hippocampal development in the mouse.

  • RESEARCH REPORT
    Hierarchical genetic interactions between FOXG1 and LHX2 regulate the formation of the cortical hem in the developing telencephalon
    Geeta Godbole, Ashwin S. Shetty, Achira Roy, Leora D'Souza, Bin Chen, Goichi Miyoshi, Gordon Fishell, Shubha Tole
    Development 2018 145: dev154583 doi: 10.1242/dev.154583 Published 9 January 2018

    Summary: The cortical hem, a telencephalic organizer that induces the hippocampus, is positionally restricted by the transcription factor FOXG1 acting directly and also by positively regulating LHX2.

  • RESEARCH ARTICLE
    The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis
    Keren Gueta, Ahuvit David, Tsadok Cohen, Yotam Menuchin-Lasowski, Hila Nobel, Ginat Narkis, LiQi Li, Paul Love, Jimmy de Melo, Seth Blackshaw, Heiner Westphal, Ruth Ashery-Padan
    Development 2016 143: 4182-4192; doi: 10.1242/dev.129734

    Summary: Ldb1 and Ldb2 have both overlapping and specific functions in mouse retinal development, specifically in maintaining the pool of retinal progenitors and for the generation of early-born photoreceptors.

  • RESEARCH ARTICLE
    Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth
    Philip Tomann, Ralf Paus, Sarah E. Millar, Claus Scheidereit, Ruth Schmidt-Ullrich
    Development 2016 143: 1512-1522; doi: 10.1242/dev.130898

    Summary: Loss of LHX2 replicates a subset of the phenotypes seen in embryos with reduced NF-κB signaling, while exogenous TGFβ2 can rescue this effect in Lhx2 knockout skin explants.

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