Lineage divergence
- Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development
Summary: Notch signaling regulates the initial emergence of medullary thymic epithelial sublineage, implicating Notch in the maintenance of primitive thymic epithelial progenitors and uncovering its cross-interaction with Foxn1.
- Dynamic transcriptional symmetry-breaking in pre-implantation mammalian embryo development revealed by single-cell RNA-seq
Highlighted article: Partitioning errors in the zygote, modulated by embryonic transcription, give rise to the unequal distribution of lineage specifiers between blastomeres that subsequently drives lineage specification.