Mid-blastula transition
- Histone concentration regulates the cell cycle and transcription in early development
Summary: Overexpression or knockdown of histones results in delayed or advanced cell cycle slowing and transcriptional activation at the mid-blastula transition, respectively, with differentially expressed genes associated with specific chromatin features.
- Cohesin facilitates zygotic genome activation in zebrafish
Summary: Cohesin contributes to dynamic changes in chromosome architecture that occur upon zygotic genome activation, raising the possibility that germline cohesinopathy mutations could lead to global alteration of the zygotic transcription program early in development.
- Modulation of temporal dynamics of gene transcription by activator potency in the Drosophila embryo
Summary: Two waves of zygotic transcription occur during the mid-blastula transition in Drosophila. Shutdown of the first wave involves post-translational modulation of the maternal factor Bicoid.