Muscle stem cell
- Satellite cell expansion is mediated by P-eIF2α-dependent Tacc3 translation
Highlighted Article: Adult stem cells require tightly regulated protein synthesis; under conditions of low protein synthesis, muscle stem cell expansion requires selective translation of Tacc3 mRNA.
- Aging induces aberrant state transition kinetics in murine muscle stem cells
Highlighted Article: Aged muscle stem cells display delayed activation dynamics, but retain a youthful activation trajectory, suggesting that changes to cell state dynamics might contribute to aging pathology.
- Multiplexed RNAscope and immunofluorescence on whole-mount skeletal myofibers and their associated stem cells
Summary: A multiplexed RNAscope in situ hybridization-immunofluorescence protocol on whole-mount skeletal myofibers and their stem cells allows sensitive spatial and quantitative analysis of transcript patterns.
- Intrinsic and extrinsic mechanisms regulating satellite cell function
Summary: This Review discusses how satellite stem cell behaviour is regulated during regeneration and degeneration by a complex balance between extrinsic cues and intrinsic regulatory mechanisms.